Article
Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han.
The Journal of clinical psychiatry - 1 Jul 2008
Yu Hui, Zhang Zhijun, Shi Yongmei, Bai Feng, Xie Chunming, Qian Yun, Yuan Yonggui, Deng Linglong
Abstract excerpt
OBJECTIVE: Experimental and clinical data suggested that brain-derived neurotrophic factor (BDNF) plays an important role in the pathogenesis of Alzheimer's disease (AD). Amnestic mild cognitive impairment (aMCI) is characterized by declined cognitive function and has a high probability of evolving into AD. The aim of this study was to investigate serum BDNF concentrations in aMCI patients and determine whether...
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