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Article

Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2015

Doi Akira, Fujimoto Ayumi, Sato Shun, Uno Takaya, Kanda Yuki, Asami Keita, Tanaka Yuriko, Kita Ayako, Satoh Ryosuke, Sugiura Reiko

Abstract excerpt

Rapamycin and its derivatives have now emerged as an attractive therapeutic strategy with both immunosuppressant and antitumor properties. In addition, rapamycin has been proposed as a calorie restriction mimetic to extend the life span of various organisms. The fission yeast Schizosaccharomyces pombe (S. pombe) serves as a valuable genetic model system to study the mechanism(s) of drug action as well as to...

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PMID: 25651869
DOI: 10.1111/gtc.12223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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