Article
Lack of association between endothelin-1 gene variants and myocardial infarction.
Journal of atherosclerosis and thrombosis - 1 Aug 2009
Palacín María, Rodriguez-Pascual Fernando, Reguero Julián R, Rodríguez Isabel, Avanzas Pablo, Lozano Iñigo, Morís Cesar, Alvarez Victoria, Cannata-Andía Jorge B, Lamas Santiago, García-Castro Monica, Coto Eliecer
Abstract excerpt
AIM: Endothelin-1 (ET-1) promotes vasoconstriction and cell proliferation, and has been implicated in hypertension and coronary artery disease. Our aim was to analyse the role of the ET-1 gene (EDN1) in the risk for atherosclerosis/myocardial infarction (MI) in a population with smoking as the prevalent risk factor. METHODS: The study included 316 patients with early onset MI (<55 years old). All were male with...
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