Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction The etude cas-témoins sur l'infarctus du myocarde (ECTIM) study

Abstract excerpt

Endothelin-1 is a potent vasoconstrictor that has also mitogenic properties, stimulating the synthesis and secretion of several vasoactive molecules. There is much evidence to suggest that endothelin-1 might be involved in the pathogenesis of hypertension, atherosclerosis, and ischemic heart disease. Endothelin-1 exerts its effects through at least two receptors, ET(A) and ET(B), which are encoded by different...

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