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Article

Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes.

Pharmacogenetics and genomics - 1 Jan 2007

Bühler Katrin, Ufer Mike, Müller-Marbach Alexis, Brinkmann Ulrich, Laule Michael, Stangl Verena, Roots Ivar, Stangl Karl, Cascorbi Ingolf

Abstract excerpt

OBJECTIVE: The potent vasoconstrictor endothelin (ET) is generated by enzymatic cleavage catalyzed by the endothelin-converting enzyme 1 (ECE-1) and plays a crucial role in the regulation of vascular tone and endothelial function. Polymorphisms of the ET and ECE genes may contribute to the development and progression of coronary artery disease. Recently, we have shown the functional relevance of the +138 adenine...

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Identifiers

PMID: 17264805
DOI: 10.1097/01.fpc.0000230118.26581.40

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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