Article
No large-effect low-frequency coding variation found for myocardial infarction.
Human molecular genetics - 1 Sept 2014
Holmen Oddgeir L, Zhang He, Zhou Wei, Schmidt Ellen, Hovelson Daniel H, Langhammer Arnulf, Løchen Maja-Lisa, Ganesh Santhi K, Mathiesen Ellisiv B, Vatten Lars, Platou Carl, Wilsgaard Tom, Chen Jin, Skorpen Frank, Dalen Håvard, Boehnke Michael, Abecasis Goncalo R, Njølstad Inger, Hveem Kristian, Willer Cristen J
Abstract excerpt
Genome-wide association studies have identified variants, primarily common, that are associated with coronary artery disease or myocardial infarction (MI), but have not tested the majority of the low frequency and rare variation in the genome. We explored the hypothesis that previously untested low frequency (1-5% minor allele frequency) and rare (<1% minor allele frequency) coding variants are associated with...
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