Article
No replication of association between estrogen receptor alpha gene polymorphisms and susceptibility to myocardial infarction in a large sample of patients of European descent.
Circulation - 4 Oct 2005
Koch Werner, Hoppmann Petra, Pfeufer Arne, Mueller Jakob C, Schömig Albert, Kastrati Adnan
Abstract excerpt
BACKGROUND: The effects of estrogen on blood vessels are partly due to changes in vascular cell gene expression and protein synthesis that are mediated by estrogen receptors. In previous association studies, the -397T/C (rs2234693) and -351A/G (rs9340799) single nucleotide polymorphisms in the estrogen receptor alpha gene (ESR1) have been implicated in the risk of coronary atherosclerosis and myocardial...
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