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Article

Polymorphism in Endothelin-1 Gene: An Overview.

Current clinical pharmacology - 1 Jan 2016

Ahmed Musa, Rghigh Abir

Abstract excerpt

Endothelin-1, (ET-1, EDN1) is an endogenous polypeptide which demonstrates dominant vasoconstriction activity and mitogenic effect. It has positive inotropic and chronotropic effects on the heart, stimulates the sympathetic and the renin-angiotensin-aldosterone systems and modifies homeostasis. The human ET-1 gene which consists of 6836 nucleotides located on chromosome 6p23-p24 produces Pre-pro-ET-1, which is...

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Source

Identifiers

PMID: 27397091
DOI: 10.2174/1574884711666160701000900

Genes

EDN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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