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Article

The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people.

Hypertension (Dallas, Tex. : 1979) - 1 May 1999

Tiret L, Poirier O, Hallet V, McDonagh T A, Morrison C, McMurray J J, Dargie H J, Arveiler D, Ruidavets J B, Luc G, Evans A, Cambien F

Abstract excerpt

There is accumulating evidence that endothelin-1 plays an important role in vascular pathophysiology. Our objective was to examine whether molecular variations at the endothelin-1 locus were involved in susceptibility to myocardial infarction and variation in blood pressure. The entire coding sequence and 1.4 kb of the 5' flanking region were screened. Five polymorphisms were detected, which were genotyped in the...

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Identifiers

PMID: 10334806
DOI: 10.1161/01.hyp.33.5.1169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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