Article
Factor V Leiden mutation is associated with enhanced arterial thrombotic tendency in lean but not in obese mice.
Thrombosis and haemostasis - 1 Oct 2007
Nagai Nobuo, Lijnen H Roger, Cleuren Audrey C A, Rosendaal Frits R, Van Hoef Berthe, Hoylaerts Marc F, Van Vlijmen Bart J M
Abstract excerpt
The homozygous factor V Leiden mutation is associated with enhanced venous thrombotic risk. Obesity is a major risk factor for development of thrombotic cardiovascular disease. It was the objective of this study to investigate whether obesity affects the thrombotic risk associated with the mutation. Male mice with homozygous factor V Leiden mutation (Arg 504 to Gln) (FVQ/Q) and corresponding wild-type (WT) mice...
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