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[Effect of alpha-galactosidase A deficiency on FV leiden fibrin deposition and thrombosis in mice].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Mar 2009

Shen Yue-Chun, He Zhao-Chu, Cai Ru-Li, Pan Jie-Zhen, Wang Xiao-Ming, Li Jun

Abstract excerpt

OBJECTIVE: To evaluate the effect of alpha-galactosidase A (Gla) deficiency on FV Leiden (FVL) associated thrombosis in vivo. METHODS: To generate the mice carrying mutations in Gla and FVL and analyze the tissue fibrin deposition in organs and thrombosis. RESULTS: In the presence of FVL, Gla deficiency greatly increased tissue fibrin deposition compared with that in wild-type [Gla(-/0) FV(Q/Q) vs. Gla(+/0)...

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PMID: 19642363

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