Article
Environmental enrichment produces a behavioral phenotype mediated by low cyclic adenosine monophosphate response element binding (CREB) activity in the nucleus accumbens.
Biological psychiatry - 1 Jan 2010
Green Thomas A, Alibhai Imran N, Roybal C Nathaniel, Winstanley Catharine A, Theobald David E H, Birnbaum Shari G, Graham Ami R, Unterberg Stephen, Graham Danielle L, Vialou Vincent, Bass Caroline E, Terwilliger Ernest F, Bardo Michael T, Nestler Eric J
Abstract excerpt
BACKGROUND: Previous research has shown that rats reared in an enriched condition (EC) are more sensitive to the acute effects of amphetamine than rats reared in an isolated condition (IC); yet, EC rats self-administer less amphetamine than IC rats. The present study used cocaine to further explore this environmental enrichment behavioral phenotype, as well as the underlying molecular mechanisms involved....
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