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Article

Proofreading dynamics of a processive DNA polymerase.

The EMBO journal - 16 Sept 2009

Ibarra Borja, Chemla Yann R, Plyasunov Sergey, Smith Steven B, Lázaro José M, Salas Margarita, Bustamante Carlos

Abstract excerpt

Replicative DNA polymerases present an intrinsic proofreading activity during which the DNA primer chain is transferred between the polymerization and exonuclease sites of the protein. The dynamics of this primer transfer reaction during active polymerization remain poorly understood. Here we describe a single-molecule mechanical method to investigate the conformational dynamics of the intramolecular DNA primer...

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Identifiers

PMID: 19661923
DOI: 10.1038/emboj.2009.219
PMCID: PMC2750014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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