Article
Escherichia coli processivity clamp β from DNA polymerase III is dynamic in solution.
Biochemistry - 5 Jul 2011
Fang Jing, Engen John R, Beuning Penny J
Abstract excerpt
Escherichia coli DNA polymerase III is a highly processive replicase because of the presence of the β clamp protein that tethers DNA polymerases to DNA. The β clamp is a head-to-tail ring-shaped homodimer, in which each protomer contains three structurally similar domains. Although multiple studies have probed the functions of the β clamp, a detailed understanding of the conformational dynamics of the β clamp in...
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