Article
A ratchet mechanism of transcription elongation and its control.
Cell - 28 Jan 2005
Bar-Nahum Gil, Epshtein Vitaly, Ruckenstein Andrei E, Rafikov Ruslan, Mustaev Arkady, Nudler Evgeny
Abstract excerpt
RNA chain elongation is a highly processive and accurate process that is finely regulated by numerous intrinsic and extrinsic signals. Here we describe a general mechanism that governs RNA polymerase (RNAP) movement and response to regulatory inputs such as pauses, terminators, and elongation factors. We show that E.coli RNAP moves by a complex Brownian ratchet mechanism, which acts prior to phosphodiester bond...
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