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Article

Genotypes of p53 codon 72 correlate with age at onset of type 1 diabetes in a sex-specific manner.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2011

Bitti Maria Luisa Manca, Saccucci Patrizia, Capasso Francesca, Piccinini Simona, Angelini Federica, Rapini Novella, Porcari Marta, Arcano Susanna, Petrelli Arianna, Del Duca Elisabetta, Bottini Egidio, Gloria-Bottini Fulvia

Abstract excerpt

In type 1 diabetes mellitus (T1D) p53 pathways are up-regulated and there is an increased susceptibility to apoptosis. The hypothesis is that p53 codon 72 polymorphism could be associated with T1D. A total of 286 children with T1D and a control sample of 730 subjects were studied. p53 codon 72 polymorphism was analysed by polymerase chain reaction. A large increase of p53 *Arg/*Arg was observed in T1D patients...

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Identifiers

PMID: 21932578
DOI: 10.1515/jpem.2011.058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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