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Article

Mutations in the exon 7 of Trp53 gene and the level of p53 protein in double transgenic mouse model of Alzheimer's disease.

Folia neuropathologica - 1 Jan 2014

Dorszewska Jolanta, Oczkowska Anna, Suwalska Monika, Rozycka Agata, Florczak-Wyspianska Jolanta, Dezor Mateusz, Lianeri Margarita, Jagodzinski Paweł P, Kowalczyk Michal J, Prendecki Michal, Kozubski Wojciech

Abstract excerpt

Alzheimer's disease (AD) leads to generation of β-amyloid (Aβ) in the brain. Alzheimer's disease model PS/APP mice show a markedly accelerated accumulation of Aβ, which may lead to apoptosis induction e.g. in cells expressing wild-type p53. The TP53 gene is found to be the most frequently mutated...

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Identifiers

PMID: 24729341
DOI: 10.5114/fn.2014.41742

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24729341-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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