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Article

The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke.

The Journal of experimental medicine - 14 Mar 2011

Gomez-Sanchez Jose C, Delgado-Esteban Maria, Rodriguez-Hernandez Irene, Sobrino Tomas, Perez de la Ossa Natalia, Reverte Silvia, Bolaños Juan P, Gonzalez-Sarmiento Rogelio, Castillo Jose, Almeida Angeles

Abstract excerpt

The functional outcome after stroke is unpredictable; it is not accurately predicted by clinical pictures upon hospital admission. The presence of apoptotic neurons in the ischemic penumbra and perihematoma area may account for poor prognosis, but whether the highly variable stroke outcome reflects differences in genetic susceptibility to apoptosis is elusive. The p53 tumor suppressor protein, an important...

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Identifiers

PMID: 21357744
DOI: 10.1084/jem.20101523
PMCID: PMC3058581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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