Article
An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease.
Neuroscience letters - 3 Apr 2003
Rosenmann Hanna, Meiner Zeev, Kahana Esther, Aladjem Zoja, Friedman Gideon, Ben-Yehuda Arie, Grenader Tal, Wertman Eli, Abramsky Oded
Abstract excerpt
Recent studies have demonstrated that p53-associated apoptosis is involved in the pathogenesis of Alzheimer's disease (AD). We performed a case-control association study between sporadic AD and the common proline/arginine polymorphism at codon 72 in the pro-apoptotic gene p53, in 109 sporadic AD patients and in 111 controls. This polymorphism has been intensively investigated for association with cancer, but so...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.