Article
Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation.
Immunity - 28 Oct 2011
Cai Yihua, Shen Xiaoyan, Ding Chuanlin, Qi Chunjian, Li Kejia, Li Xia, Jala Venkatakrishna R, Zhang Huang-ge, Wang Tian, Zheng Jie, Yan Jun
Abstract excerpt
Interleukin-23 (IL-23) and CD4(+) T helper 17 (Th17) cells are thought to be critical in psoriasis pathogenesis. Here, we report that IL-23 predominantly stimulated dermal γδ T cells to produce IL-17 that led to disease progression. Dermal γδ T cells constitutively expressed the IL-23 receptor (IL-23R) and transcriptional factor RORγt. IL-17 production from dermal γδ T cells was independent of αβ T cells. The...
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