Article
IL-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2008
Quinn Julian M W, Sims Natalie A, Saleh Hasnawati, Mirosa Danijela, Thompson Keith, Bouralexis Stelios, Walker Emma C, Martin T John, Gillespie Matthew T
Abstract excerpt
IL-23 stimulates the differentiation and function of the Th17 subset of CD4(+) T cells and plays a critical role in chronic inflammation. The IL-23 receptor-encoding gene is also an inflammatory disease susceptibility gene. IL-23 shares a common subunit with IL-12, a T cell-dependent osteoclast formation inhibitor, and we found that IL-23 also dose-dependently inhibited osteoclastogenesis in a CD4(+) T...
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