Article
The role of IL-23/IL-17 axis in human kidney allograft rejection.
Journal of leukocyte biology - 1 Dec 2018
Haouami Youssra, Dhaouadi Tarak, Sfar Imen, Bacha Mongi, Gargah Tahar, Bardi Rafika, Abderrahim Ezzeddine, Goucha Rym, Ben Abdallah Taïeb, Gorgi Yousr
Abstract excerpt
Th17 cell subset has been implicated in autoimmune diseases, tumor immunity and, transplant rejection. In order to investigate the role of IL-17/IL-23 pathway in allograft outcome, intragraft expression of IL-17 mRNA and single nucleotide polymorphisms (SNPs) of IL-17A, IL-17F, IL-17RC, and IL23R genes were evaluated with a quantification of IL-17A, IL-17F, and IL-23 plasma levels. This study revealed that...
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