Article
Use of modified U1 snRNAs to inhibit HIV-1 replication.
Nucleic acids research - 1 Jan 2007
Sajic R, Lee K, Asai K, Sakac D, Branch D R, Upton C, Cochrane A
Abstract excerpt
Control of RNA processing plays a central role in regulating the replication of HIV-1, in particular the 3' polyadenylation of viral RNA. Based on the demonstration that polyadenylation of mRNAs can be disrupted by the targeted binding of modified U1 snRNA, we examined whether binding of U1 snRNAs to conserved 10 nt regions within the terminal exon of HIV-1 was able to inhibit viral structural protein expression....
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