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Article

A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.

Cancer research - 15 Aug 2009

Min Chengyin, Yu Ziyang, Kirsch Kathrin H, Zhao Yingshe, Vora Siddharth R, Trackman Philip C, Spicer Douglas B, Rosenberg Lynn, Palmer Julie R, Sonenshein Gail E

Abstract excerpt

The lysyl oxidase (LOX) gene reverted Ras transformation of NIH 3T3 fibroblasts and tumor formation by gastric cancer cells, which frequently carry mutant RAS genes. The secreted lysyl oxidase proenzyme is processed to a propeptide (LOX-PP) and a functional enzyme (LOX). Unexpectedly, the tumor suppressor activity mapped to the LOX-PP domain, which inhibited tumor formation and the invasive phenotype of NF639...

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Source

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Identifiers

PMID: 19654310
DOI: 10.1158/0008-5472.CAN-08-4818
PMCID: PMC2729564

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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