A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer.

doi:10.1093/carcin/bgy045

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A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer.

Carcinogenesis - 3 Jul 2018

de la Cueva Ana, Emmerling Michael, Lim Sarah L, Yang Shi, Trackman Philip C, Sonenshein Gail E, Kirsch Kathrin H

Abstract excerpt

The propeptide (LOX-PP) domain of the lysyl oxidase proenzyme was shown to inhibit the transformed phenotype of breast, lung and pancreatic cells in culture and the formation of Her2/neu-driven breast cancer in a xenograft model. A single nucleotide polymorphism (SNP, rs1800449) positioned in a highly conserved region of LOX-PP results in an Arg158Gln substitution (humans). This arginine (Arg)→glutamine (Gln)...

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PMID: 29579155
DOI: 10.1093/carcin/bgy045
PMCID: PMC6692853

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