A loss-of-function polymorphism in the propeptide of lysyl oxidase exacerbates atherosclerosis.

doi:10.1172/jci.insight.201535

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Article

A loss-of-function polymorphism in the propeptide of lysyl oxidase exacerbates atherosclerosis.

JCI insight - 22 Jul 2026

Jung In-Hyuk, Amrute Junedh M, Luna Sofia E, Wagoner Ryan E, Alisio Arturo, Lee Paul C, Burks Kendall H, Oh Joohee, Plunkett Paletta Hannah C, Kang Chul Joo, Stitziel Nathan O

Abstract excerpt

A single-nucleotide missense polymorphism (rs1800449, R158Q) in the propeptide domain of lysyl oxidase (LOX-PP) is associated with increased risk of coronary artery disease (CAD) independent of changes in plasma lipid levels. Although the enzymatic function of LOX has an essential role for the cross-linking of extracellular matrix proteins in connective tissues, whether and how LOX-PP R158Q contributes to the...

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PMID: 42484377
DOI: 10.1172/jci.insight.201535
PMCID: PMC13461166

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