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Article

The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.

Cancer research - 1 Feb 2007

Min Chengyin, Kirsch Kathrin H, Zhao Yingshe, Jeay Sébastien, Palamakumbura Amitha H, Trackman Philip C, Sonenshein Gail E

Abstract excerpt

Expression of the lysyl oxidase gene (LOX) was found to inhibit the transforming activity of the ras oncogene in NIH 3T3 fibroblasts and was hence named the ras recision gene (rrg). Lysyl oxidase (LOX) is synthesized and secreted as a 50-kDa inactive proenzyme (Pro-LOX), which is processed by proteolytic cleavage to a functional 32-kDa enzyme and an 18-kDa propeptide (LOX-PP). Recently, the ras recision activity...

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Source

Identifiers

PMID: 17283144
DOI: 10.1158/0008-5472.CAN-06-3867

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.PMID 17283144Read ↗

Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells.Semantic proximity Read ↗

A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.Semantic proximity Read ↗

The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model.Semantic proximity Read ↗

Lysyl Oxidases Expression and Breast Cancer Progression: A Bioinformatic AnalysisSemantic proximity Read ↗

Lysyl oxidases: linking structures and immunity in the tumor microenvironmentSemantic proximity Read ↗

The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.Semantic proximity Read ↗

LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling.Semantic proximity Read ↗

Selective expression of lysyl oxidase (LOX) in the stromal reactions of broncho-pulmonary carcinomas.Semantic proximity Read ↗

A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer.Semantic proximity Read ↗

Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide.Semantic proximity Read ↗

Differential expression of the LOX family genes in human colorectal adenocarcinomasSemantic proximity Read ↗

Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancySemantic proximity Read ↗

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