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Lysyl Oxidases Expression and Breast Cancer Progression: A Bioinformatic Analysis

21 Jun 2022

Abstract excerpt

LOX (Lysyl oxidase) and LOX like 1–4 (LOXL1–4) are amine oxidases that catalyse the cross-linking of elastin and collagen in the extracellular matrix (ECM). This activity can facilitate cell migration and the formation of metastases. Consequently, inhibition of these enzymes and, in particular of LOXL2, has been suggested as a therapeutic strategy to prevent breast cancer metastasis. Although medicinal chemistry...

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Identifiers

PMID: 35800439
DOI: 10.3389/fphar.2022.883998

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