Article
Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells.
Cancer research - 1 Jul 2007
Wu Min, Min Chengyin, Wang Xiaobo, Yu Ziyang, Kirsch Kathrin H, Trackman Philip C, Sonenshein Gail E
Abstract excerpt
The gene encoding lysyl oxidase (LOX) was identified as the ras recision gene (rrg), with the ability to revert Ras-mediated transformation of NIH 3T3 fibroblasts. Mutations in RAS genes have been found in approximately 25% of lung cancers and in 85% of pancreatic cancers. In microarray analysis, these cancers were found to display reduced LOX gene expression. Thus, the ability of the LOX gene to repress the...
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