Association of the G473A polymorphism and expression of lysyl oxidase with breast cancer risk and survival in European women: a hospital-based case-control study.

doi:10.1371/journal.pone.0105579

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Article

Association of the G473A polymorphism and expression of lysyl oxidase with breast cancer risk and survival in European women: a hospital-based case-control study.

PloS one - 1 Jan 2014

Friesenhengst Andrea, Pribitzer-Winner Tamara, Schreiber Martin

Abstract excerpt

BACKGROUND: Lysyl oxidase (LOX) is an extracellular enzyme essential for the covalent crosslinking of extracellular matrix proteins and may also have additional functions. LOX expression can be both up- and downregulated in cancer and is associated both with tumour suppression and metastasis progression. The G473A polymorphism (rs1800449) results in the Arg158Gln amino acid substitution in the LOX propeptide,...

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PMID: 25141126
DOI: 10.1371/journal.pone.0105579
PMCID: PMC4139364

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