Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A phylogenetic and Markov model approach for the reconstruction of mutational pathways of drug resistance.

Bioinformatics (Oxford, England) - 1 Oct 2009

Buendia Patricia, Cadwallader Brice, DeGruttola Victor

Abstract excerpt

MOTIVATION: Modern HIV-1, hepatitis B virus and hepatitis C virus antiviral therapies have been successful at keeping viruses suppressed for prolonged periods of time, but therapy failures attributable to the emergence of drug resistant mutations continue to be a distressing reminder that no therapy can fully eradicate these viruses from their host organisms. To better understand the emergence of drug resistance,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Drug Resistance, Viral
Share to HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Markov Chains

Share to Mutation

Share to Phylogeny

Share to Viruses

Source

Open in PubMed Open full text

Identifiers

PMID: 19654117
DOI: 10.1093/bioinformatics/btp466
PMCID: PMC2752619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A phylogenetic and Markov model approach for the reconstruction of mutational pathways of drug resistance.PMID 19654117Read ↗

Discovering human immunodeficiency virus mutational pathways using temporal Bayesian networks.Semantic proximity Read ↗

The Role of Phylogenetics as a Tool to Predict the Spread of Resistance.Semantic proximity Read ↗

Forecasting drug resistant HIV protease evolutionSemantic proximity Read ↗

Exploring evolutionary trajectories of drug resistance.Semantic proximity Read ↗

Comparing mutational pathways to lopinavir resistance in HIV-1 subtypes B versus CSemantic proximity Read ↗

Modeling Drug Resistance Emergence and Transmission in HIV-1 in the UK.Semantic proximity Read ↗

Forecasting drug resistant HIV protease evolution.Semantic proximity Read ↗

Evolution of drug resistance in HIV protease.Semantic proximity Read ↗

A mutagenetic tree hidden Markov model for longitudinal clonal HIV sequence dataSemantic proximity Read ↗

Estimating HIV evolutionary pathways and the genetic barrier to drug resistance.Semantic proximity Read ↗

A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations.Semantic proximity Read ↗

Drug resistance mutations in HIV: new bioinformatics approaches and challenges.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.