Article
A mutagenetic tree hidden Markov model for longitudinal clonal HIV sequence data
28 Mar 2006
Abstract excerpt
RNA viruses provide prominent examples of measurably evolving populations. In human immunodeficiency virus (HIV) infection, the development of drug resistance is of particular interest because precise predictions of the outcome of this evolutionary process are a prerequisite for the rational design of antiretroviral treatment protocols. We present a mutagenetic tree hidden Markov model for the analysis of...
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