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Article

Estimating HIV evolutionary pathways and the genetic barrier to drug resistance.

The Journal of infectious diseases - 1 Jun 2005

Beerenwinkel Niko, Däumer Martin, Sing Tobias, Rahnenfuhrer Jörg, Lengauer Thomas, Selbig Joachim, Hoffmann Daniel, Kaiser Rolf

Abstract excerpt

BACKGROUND: The evolution of drug-resistant viruses challenges the management of human immunodeficiency virus (HIV) infections. Understanding this evolutionary process is important for the design of effective therapeutic strategies. METHODS: We used mutagenetic trees, a family of probabilistic graphical models, to describe the accumulation of resistance-associated mutations in the viral genome. On the basis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15871130
DOI: 10.1086/430005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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