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Article

A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations.

eLife - 22 Dec 2023

Eccleston Ruth Charlotte, Manko Emilia, Campino Susana, Clark Taane G, Furnham Nicholas

Abstract excerpt

Pathogen evolution of drug resistance often occurs in a stepwise manner via the accumulation of multiple mutations that in combination have a non-additive impact on fitness, a phenomenon known as epistasis. The evolution of resistance via the accumulation of point mutations in the DHFR genes of Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) has been studied extensively and multiple studies have shown...

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Identifiers

PMID: 38132182
DOI: 10.7554/eLife.84756
PMCID: PMC10807863

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