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Article

Identification of a Cell-Type-Specific and E2F-Independent Mechanism for Repression of cdc2 Transcription

1 Jun 1995

Abstract excerpt

Human myeloid leukemia cells, such as HL60, U937, and THP1 cells, undergo macrophage differentiation and growth arrest following treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Surprisingly, we find that growth of a significant percentage of THP1 cells is arrested in the G2 phase of the cell cycle. G2 arrest correlates with cell-specific repression of the gene encoding p34cdc2, a...

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Identifiers

PMID: 7760824
DOI: 10.1128/mcb.15.6.3282

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