Article
The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999
Dougherty K M, Pearson J M, Yang A Y, Westrick R J, Baker M S, Ginsburg D
Abstract excerpt
Plasminogen activator inhibitor-2 (PAI-2), a member of the serpin gene family, is thought to serve as a primary regulator of plasminogen activation in the extravascular compartment. High levels of PAI-2 are found in keratinocytes, monocytes, and the human trophoblast, the latter suggesting a role in placental maintenance or embryo development. The primarily intracellular distribution of PAI-2 also may indicate a...
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