Article
The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999
Dougherty K M, Pearson J M, Yang A Y, Westrick R J, Baker M S, Ginsburg D
Abstract excerpt
Plasminogen activator inhibitor-2 (PAI-2), a member of the serpin gene family, is thought to serve as a primary regulator of plasminogen activation in the extravascular compartment. High levels of PAI-2 are found in keratinocytes, monocytes, and the human trophoblast, the latter suggesting a role...
Topics
- Animals
- Blotting, Southern
- Gene Targeting
- Genotype
- Mice
- Mice, Knockout
- Molecular Sequence Data
- Monocytes
- Phenotype
- Plasminogen Activator Inhibitor 1
- Plasminogen Activator Inhibitor 2
- Stem Cells
- Wound Healing