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Article

The molecular basis for the aberrant production of plasminogen activator inhibitor type 2 in THP-1 monocytes.

Thrombosis and haemostasis - 1 Sept 2000

Katsikis J, Yu H, Maurer F, Medcalf R

Abstract excerpt

Plasminogen activator inhibitor type 2 (PAI-2) is a urokinase inhibitor that is expressed primarily in monocytes. THP-1 monocytes, however. contain a unique defect in the production of PAI-2 in that the PAI-2 transcript is truncated and the expressed protein inactive (1). Here we describe the basis of this mutation in THP-1 cells. Southern blot analysis of THP-1-derived genomic DNA indicated that there were no...

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Identifiers

PMID: 11019973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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