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Article

Protein kinase C-beta is required for macrophage differentiation of human HL-60 leukemia cells.

The Journal of biological chemistry - 16 Sept 1994

Tonetti D A, Henning-Chubb C, Yamanishi D T, Huberman E

Abstract excerpt

The requirement for protein kinase C (PKC)-beta in phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of human HL-60 promyelocytic leukemia cells was studied by using the variant HL-525, which is deficient in PKC-beta and is resistant to PMA-induced differentiation. Transfec...

Topics

Cell Differentiation
DNA, Complementary
Drug Resistance
Humans
Leukemia
Macrophages
Phenotype
Protein Kinase C
Protein Kinase C beta
Signal Transduction
Tetradecanoylphorbol Acetate
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 8083228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8083228-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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