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Article

Genetics of SLE: does this explain susceptibility and severity across racial groups?

Rheumatology (Oxford, England) - 29 Mar 2023

Demkova Karin, Morris David L, Vyse Timothy J

Abstract excerpt

The prevalence and severity of SLE have been found to vary across populations of different ancestries. This review explores whether these differences can be explained by the genetic aetiology of the condition. Large genetic studies suggest that populations of different ancestry share the same risk loci but individual risk alleles are more common in some, leading to a higher prevalence and severity and an earlier...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Single Nucleotide

Share to Prevalence

Share to Racial Groups

Share to RNA regulation and disease

Share to Systemic Lupus Erythematosus Research

Source

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Identifiers

PMID: 36583554
DOI: 10.1093/rheumatology/keac695
PMCID: PMC10050932

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