Article
Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis.
Arthritis research & therapy - 1 Jan 2010
Burgos Paula I, Causey Zenoria L, Tamhane Ashutosh, Kelley James M, Brown Elizabeth E, Hughes Laura B, Danila Maria I, van Everdingen Amalia, Conn Doyt L, Jonas Beth L, Callahan Leigh F, Smith Edwin A, Brasington Richard D, Moreland Larry W, van der Heijde Désirée M, Alarcón Graciela S, Bridges S Louis
Abstract excerpt
INTRODUCTION: To determine whether IL4R single-nucleotide polymorphisms (SNPs) rs1805010 (I50V) and rs1801275 (Q551R), which have been associated with disease severity in rheumatoid arthritis (RA) patients of European ancestry, relate to the presence of rheumatoid nodules and radiographic erosions in African Americans. METHODS: Two IL4R SNPs, rs1805010 and rs1801275, were genotyped in 749 patients from the...