Article
Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults.
PloS one - 1 Jul 2009
Rathcke Camilla Noelle, Holmkvist Johan, Husmoen Lise Lotte N, Hansen Torben, Pedersen Oluf, Vestergaard Henrik, Linneberg Allan
Abstract excerpt
BACKGROUND: YKL-40 is a chitinase-like glycoprotein encoded by the chitinase 3-like 1 gene, CHI3L1, localized at chromosome 1q32.1. Increased levels of serum YKL-40 have been reported to be a biomarker for asthma and a reduced lung function. Interestingly, the C-allele of the -131 C-->G (rs4950928) polymorphism of CHI3L1 has been shown to associate with bronchial hyperresponsiveness and reduced lung function...
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