Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin.

doi:10.1016/j.mce.2009.06.015

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Article

Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin.

Molecular and cellular endocrinology - 5 Mar 2010

Lin Hai-Yan, Muller Yves A, Hammond Geoffrey L

Abstract excerpt

Corticosteroid-binding globulin (CBG), a non-inhibitory member of the serine proteinase inhibitor (serpin) super-family, is the high-affinity transport protein for glucocorticoids in vertebrate blood. Plasma CBG is a glycoprotein with 30% of its mass represented by N-linked oligosaccharide chains. Its well-characterized steroid-binding properties represent a "bench-mark data set" used extensively for in silico...

Topics

Allosteric Regulation
Animals
Antithrombins
Binding Sites
Crystallography, X-Ray
Genetic Variation
Humans
Models, Molecular
Molecular Sequence Data
Protein Binding
Protein Conformation
Steroids
Thyroxine-Binding Globulin
Transcortin

Source

Open in PubMed

Identifiers

PMID: 19643161
DOI: 10.1016/j.mce.2009.06.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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