Article
Corticosteroid-Binding Globulin: A Review of Basic and Clinical Advances.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Jun 2016
Meyer E J, Nenke M A, Rankin W, Lewis J G, Torpy D J
Abstract excerpt
Corticosteroid-binding globulin (CBG, transcortin) is the primary cortisol binding protein. It is a non-inhibitory serine protease inhibitor, capable of conformational change from a high cortisol-binding affinity form to a low affinity form upon cleavage of its reactive centre loop by various proteases, such as neutrophil elastase. The burgeoning inflammatory role of CBG applies to acute, severe inflammation...
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