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Article

Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage.

The Journal of biological chemistry - 9 Jan 2009

Lin Hai-Yan, Underhill Caroline, Gardill Bernd R, Muller Yves A, Hammond Geoffrey L

Abstract excerpt

Corticosteroid-binding globulin (CBG) is a non-inhibitory serine proteinase inhibitor (serpin) that transports cortisol and progesterone in blood. Crystal structures of rat CBG and a thrombin-cleaved human CBG:anti-trypsin (Pittsburgh) chimera show how structural transitions after proteolytic cleavage of the CBG reactive center loop (RCL) could disrupt steroid binding. This ligand release mechanism is assumed to...

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PMID: 19011238
DOI: 10.1074/jbc.M807376200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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