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Article

High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects.

The Journal of clinical endocrinology and metabolism - 1 Apr 2012

Lin Hai-Yan, Underhill Caroline, Lei Jing-Hui, Helander-Claesson Anna, Lee Hwa-Yong, Gardill Bernd R, Muller Yves A, Wang Hongmei, Hammond Geoffrey L

Abstract excerpt

CONTEXT: Cortisol is transported by corticosteroid-binding globulin (CBG) in blood. Single nucleotide polymorphisms (SNP) in the human CBG (SERPINA6) gene that disrupt CBG production or steroid binding are considered rare. OBJECTIVE: The objective of the study was to identify and determine the frequency of SNP in SERPINA6 that influence the production or cortisol-binding properties of CBG in Chinese subjects....

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Source

Identifiers

PMID: 22337907
DOI: 10.1210/jc.2011-3141

Genes

SERPINA6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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