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Article

Effect of mutations of the human serpin protein corticosteroid-binding globulin on cortisol-binding, thermal and protease sensitivity.

The Journal of steroid biochemistry and molecular biology - 1 May 2010

Braun Beate C, Meyer Hellmuth-A, Reetz Antje, Fuhrmann Ulrike, Köhrle Josef

Abstract excerpt

Corticosteroid-binding globulin (CBG, transcortin) belongs to the serpin family of serine protease inhibitors (SERPINA6) and is mainly secreted by the liver. The negative acute phase protein CBG regulates free cortisol levels in the blood and distributes cortisol to its target tissues. So far no CBG serpin partner protease has been identified. However, its cleavage by human neutrophil elastase destroys ligand...

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Source

Identifiers

PMID: 20226861
DOI: 10.1016/j.jsbmb.2010.03.014

Genes

SERPINA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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