Article
Naturally occurring mutations of human corticosteroid-binding globulin.
The Journal of clinical endocrinology and metabolism - 1 Jan 2015
Simard Marc, Hill Lesley A, Lewis John G, Hammond Geoffrey L
Abstract excerpt
CONTEXT: Corticosteroid-binding globulin (CBG) is encoded by SERPINA6. It is the major plasma binding protein of glucocorticoids and regulates plasma cortisol levels and bioavailability in humans. Several proteases target CBG and disrupt its steroid-binding properties. To date, most genetic deficiencies that alter plasma CBG levels or function have been identified in patients presenting with a variety of clinical...
Topics
- Animals
- CHO Cells
- Cricetulus
- Databases, Genetic
- Humans
- Hydrocortisone
- Mutation
- Polymorphism, Single Nucleotide
- Transcortin