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Article

Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis.

The Biochemical journal - 1 Jul 2002

Grasberger Helmut, Golcher Henriette M B, Fingerhut Anja, Janssen Onno E

Abstract excerpt

Thyroxine-binding globulin (TBG) and corticosteroid-binding globulin are unique among non-inhibitory members of the superfamily of serine-proteinase inhibitors (serpins) in undergoing a dramatic increase in stability [stressed-to-relaxed (S-->R) transition] after proteolytic cleavage within their exposed reactive-site-loop (RSL) equivalent. This structural rearrangement involves the insertion of the cleaved loop...

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Identifiers

PMID: 11931635
DOI: 10.1042/BJ20020014
PMCID: PMC1222644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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