Article
Two different corticosteroid-binding globulin variants that lack cortisol-binding activity in a greek woman.
The Journal of clinical endocrinology and metabolism - 1 Nov 2012
Hill L A, Vassiliadi D A, Simard M, Pavlaki A, Perogamvros I, Hadjidakis D, Hammond G L
Abstract excerpt
BACKGROUND: Corticosteroid-binding globulin (CBG), encoded by SERPINA6, is the principal plasma binding protein for cortisol. Most nonsynonymous single-nucleotide polymorphisms that alter the production or function of CBG occur rarely, and their clinical significance remains obscure. METHODS: Serum and DNA were obtained from a Greek woman with low morning cortisol levels and from family members. SERPINA6 exons...
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