Article
Novel corticosteroid-binding globulin variant that lacks steroid binding activity.
The Journal of clinical endocrinology and metabolism - 1 Oct 2010
Perogamvros I, Underhill C, Henley D E, Hadfield K D, Newman W G, Ray D W, Lightman S L, Hammond G L, Trainer P J
Abstract excerpt
BACKGROUND: Corticosteroid-binding globulin (CBG) is the principal carrier for glucocorticoids in the circulation and a regulator of their bioavailability. Inherited CBG deficiencies are rarely reported, and only three causative mutations in four families have been described. PATIENTS, METHODS, AND RESULTS: In a 26-yr-old female with hypotension, fatigue, and undetectable total serum cortisol at presentation, we...
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